Darius Babusis Selected Research

Infections

1/2023	Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys.
11/2021	Two-dose emtricitabine/tenofovir alafenamide plus bictegravir prophylaxis protects macaques against SHIV infection.
10/2020	Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.
10/2019	Efficacy of Oral Tenofovir Alafenamide/Emtricitabine Combination or Single-Agent Tenofovir Alafenamide Against Vaginal Simian Human Immunodeficiency Virus Infection in Macaques.
1/2018	Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment.
1/2017	Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.
1/2017	Viability of primary osteoblasts after treatment with tenofovir alafenamide: Lack of cytotoxicity at clinically relevant drug concentrations.
10/2016	Chemoprophylaxis With Oral Emtricitabine and Tenofovir Alafenamide Combination Protects Macaques From Rectal Simian/Human Immunodeficiency Virus Infection.
1/2015	Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy.
1/2012	Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides.

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Darius Babusis Research Topics

Disease

12	COVID-19 03/2024 - 01/2021
10	Infections 01/2023 - 01/2012
4	Virus Diseases (Viral Diseases) 01/2021 - 01/2017
3	Neoplasms (Cancer) 01/2014 - 05/2009
3	Lymphoma (Lymphomas) 01/2014 - 01/2013
2	Inflammation (Inflammations) 03/2024 - 11/2023
1	Respiratory Tract Diseases (Respiratory Tract Disease) 01/2022
1	Coronavirus Infections 01/2022
1	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2022
1	Severe Acute Respiratory Syndrome 01/2021
1	Hepatitis C 06/2020
1	Hepatocellular Carcinoma (Hepatoma) 01/2018
1	Ebola Hemorrhagic Fever 01/2017
1	Leukemia 01/2014
1	Hypercalcemia (Milk Alkali Syndrome) 01/2014
1	Cytopenia 01/2014
1	Multiple Myeloma 01/2014
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2012
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 05/2009

Drug/Important Bio-Agent (IBA)

12	Antiviral Agents (Antivirals)IBA 06/2023 - 01/2012
11	ProdrugsIBA 03/2024 - 05/2009
9	remdesivirIBA 03/2024 - 01/2017
5	NucleotidesIBA 02/2022 - 05/2009
3	NucleosidesIBA 03/2024 - 01/2018
3	VaccinesIBA 06/2023 - 01/2017
3	GS-441524IBA 01/2022 - 09/2021
3	tenofovir alafenamideIBA 10/2019 - 01/2015
3	Emtricitabine (Emtriva)FDA Link 10/2019 - 10/2016
2	GS-621763IBA 01/2022 - 09/2021
2	Adenosine (Adenocard)FDA LinkGeneric 01/2021 - 01/2021
2	triphosphoric acid (triphosphate)IBA 01/2021 - 01/2018
2	SofosbuvirIBA 06/2020 - 01/2018
2	ProTidesIBA 06/2020 - 01/2017
2	RacivirIBA 10/2019 - 10/2016
2	GuanineIBA 01/2014 - 05/2009
2	rabacfosadineIBA 01/2014 - 05/2009
2	9-((2-phosphonylmethoxy)ethyl)guanineIBA 01/2014 - 05/2009
2	pomalidomideIBA 01/2013 - 01/2013
1	bictegravirIBA 11/2021
1	emtricitabine tenofovir alafenamideIBA 11/2021
1	COVID-19 VaccinesIBA 09/2021
1	GS-441524 triphosphateIBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	EnzymesIBA 01/2021
1	Lopinavir FDA Link 10/2020
1	Interferon-betaIBA 10/2020
1	Ritonavir (Norvir)FDA Link 10/2020
1	Ribavirin (Virazole)FDA LinkGeneric 01/2018
1	elvitegravirIBA 01/2017
1	TabletsIBA 01/2017
1	CobicistatIBA 01/2017
1	Tenofovir (Viread)FDA Link 01/2015
1	Melphalan (Alkeran)FDA LinkGeneric 01/2014
1	ParaproteinsIBA 01/2014
1	Interleukin-2 (IL2)IBA 01/2013
1	Lenalidomide (CC 5013)FDA Link 01/2013
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2013
1	RibonucleosidesIBA 01/2012

Therapy/Procedure

4	Therapeutics 06/2023 - 01/2014
1	Treatment Delay 03/2024
1	Euthanasia (Mercy Killing) 11/2023
1	Liver Transplantation 01/2018
1	Chemoprevention 10/2016
1	Drug Therapy (Chemotherapy) 05/2009